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Full implementation would require legislative action but is politically feasible if framed as "preventing manufacturers from gaming negotiation timelines." Long term (5+ years) : Accelerate generic and biosimilar entry

Understanding the timeline for results and the factors that influence effectiveness empowers you to take an active role in your treatment

This month, two new studies help close the loop: Study #1 (Lancet eBioMedicine, July 2025): Longitudinal plasma proteomics in ~100 humans before and after metformin revealed 23 consistently altered proteins

Although there have been conflicting reports on the effects of the incretin class of drugs on the pancreas in animal studies, this is the first study to note such changes in the human pancreas